article Open AccessTop 1% cited
Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response
Molecular Cell · 2000 · Vol. 5(5) · pp. 897–904
Heather P. Harding(New York University)Yuhong Zhang(New York University)Anne Bertolotti(New York University)Huiqing Zeng(New York University)David Ron✉(New York University)
Endoplasmic Reticulum Stress and DiseaseRNA regulation and diseaseAutophagy in Disease and TherapyUnfolded protein responseEndoplasmic reticulumBiologyTranslation (biology)CycloheximideCell biologyProtein biosynthesisPhosphorylationEukaryotic initiation factoreIF2
MeSH terms
Adaptation, PhysiologicalAnimalsCell SurvivalCycloheximideEndoplasmic ReticulumGene Expression RegulationMutationPhosphorylationProtein Synthesis InhibitorsProtein BiosynthesisTunicamycinEukaryotic Initiation Factor-2Protein FoldingeIF-2 KinaseMice
Citations
1,997
FWCI
15.53
field-weighted impact
References
25
Percentile
100%
vs. same field & year
Citations per year
Cited by
ATF6 Activated by Proteolysis Binds in the Presence of NF-Y (CBF) Directly to the<i>cis</i>-Acting Element Responsible for the Mammalian Unfolded Protein Response
Molecular and Cellular Biology · 2000 · 934 citations
The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus
Endocrine Reviews · 2007 · 1,158 citations
Pharmacological brake-release of mRNA translation enhances cognitive memory
eLife · 2013 · 729 citations
Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus.
The EMBO Journal · 1996 · 1,252 citations
<b>Stress Granule Assembly Is Mediated by Prion-like Aggregation of TIA-1</b>
Molecular Biology of the Cell · 2004 · 994 citations
The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase
Molecular and Cellular Biology · 2004 · 967 citations
Feedback Inhibition of the Unfolded Protein Response by <i>GADD34</i>-Mediated Dephosphorylation of eIF2α
The Journal of Cell Biology · 2001 · 1,357 citations
Cellular response to endoplasmic reticulum stress: a matter of life or death
Cell Death and Differentiation · 2006 · 682 citations
References
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls
Genes & Development · 1999 · 2,249 citations
Translational control
Journal of Cellular Biochemistry · 1991 · 432 citations
Related articles
Regulation of Herpesvirus Macromolecular Synthesis I. Cascade Regulation of the Synthesis of Three Groups of Viral Proteins
Journal of Virology · 1974 · 1,420 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.