article Open AccessTop 1% cited
DNA methylation age of human tissues and cell types
Genome biology · 2013 · Vol. 14(10) · pp. R115–R115
Steve Horvath✉(University of California, Los Angeles)
Abstract
I propose that DNA methylation age measures the cumulative effect of an epigenetic maintenance system. This novel epigenetic clock can be used to address a host of questions in developmental biology, cancer and aging research.
Epigenetics and DNA MethylationGenomics and Chromatin DynamicsRNA modifications and cancerBiologyDNA methylationEpigeneticsCpG siteSomatic cellMethylationGeneticsChromatinCancerComputational biology
MeSH terms
Age FactorsAgingAnimalsBlood CellsBrainPan troglodytesChromatinGene Expression RegulationHumansModels, BiologicalMutationNeoplasmsOrgan SpecificityProgeriaReceptors, Steroid
Funding
- University of Southern California
Citations
7,042
FWCI
71.16
field-weighted impact
References
92
Percentile
100%
vs. same field & year
Citations per year
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PLoS Genetics · 2012 · 715 citations
Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma
Cancer Cell · 2012 · 1,844 citations
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