articleTop 1% cited
Mesenchymal Stem Cells Inhibit Dendritic Cell Differentiation and Function by Preventing Entry Into the Cell Cycle
Transplantation · 2007 · Vol. 83(1) · pp. 71–76
Rajesh Ramasamy(Imperial College London)Henrietta Fazekasova(King's College London)Eric W.‐F. Lam(Imperial College London)In s Soeiro(Imperial College London)Giovanna Lombardi(King's College London)Francesco Dazzi✉(Hammersmith Hospital)
Abstract
We conclude that MSCs impair monocyte differentiation and function by interfering with the cell cycle. These findings imply that MSC-induced immunosuppression might be a side product of a more general antiproliferative effect.
Mesenchymal stem cell researchImmune cells in cancerImmunotherapy and Immune ResponsesMesenchymal stem cellMonocyteCell biologyCell cycleHaematopoiesisImmunologyBone marrowCellular differentiationBiologyDendritic cell
MeSH terms
Bone Marrow CellsCell CycleCell DifferentiationDendritic CellsHumansLymphocyte ActivationMonocytesCD4-Positive T-LymphocytesAntigens, CDInterleukin-4ImmunophenotypingGranulocyte-Macrophage Colony-Stimulating FactorCyclinsCyclin D2Mesenchymal Stem Cells
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458
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References
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The Journal of Experimental Medicine · 1999 · 1,603 citations
Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase–mediated tryptophan degradation
Blood · 2004 · 1,627 citations
Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells
Transplantation · 2003 · 663 citations
Human mesenchymal stem cells modulate allogeneic immune cell responses
Blood · 2004 · 4,508 citations
Human mesenchymal stem cells modulate B-cell functions
Blood · 2005 · 1,742 citations
Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
Blood · 2002 · 3,188 citations
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