articleTop 10% cited
Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells
Transplantation · 2003 · Vol. 76(8) · pp. 1208–1213
Ida Rasmusson✉(Karolinska Institutet)Olle Ringdén(Karolinska Institutet)Berit Sundberg(Karolinska University Hospital)Katarina Le Blanc(Karolinska University Hospital)
Abstract
Our findings indicate that MSCs escape recognition by CTLs and alloreactive NK cells, and inhibit the formation of cytotoxic T cells by secreting a soluble factor, but that they do not interfere with CTLs and NK cell lysis.
Mesenchymal stem cell researchImmune Cell Function and InteractionHematopoietic Stem Cell TransplantationCytotoxic T cellMesenchymal stem cellLymphokine-activated killer cellInterleukin 12K562 cellsBiologyImmunologyInterleukin 21LysisChemistry
MeSH terms
Cell DivisionCells, CulturedHumansKiller Cells, NaturalLymphocyte ActivationMesodermStem CellsT-Lymphocytes, CytotoxicTime Factors
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663
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9.27
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27
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98%
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References
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Blood · 1990 · 2,754 citations
Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide
Blood · 2003 · 1,588 citations
Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation
Transplantation · 2003 · 1,493 citations
Characterization of cells with osteogenic potential from human marrow
Bone · 1992 · 1,287 citations
Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
Blood · 2002 · 3,188 citations
Multilineage Potential of Adult Human Mesenchymal Stem Cells
Science · 1999 · 20,977 citations
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