review Open AccessTop 1% cited
Molecular and cellular insights into T cell exhaustion
Nature reviews. Immunology · 2015 · Vol. 15(8) · pp. 486–499
E. John Wherry✉(University of Pennsylvania)Makoto Kurachi(University of Pennsylvania)
Immune Cell Function and InteractionT-cell and B-cell ImmunologyCancer Immunotherapy and BiomarkersEffectorBiologyImmunologyCellImmunityCancerT cellReceptorFunction (biology)Cancer research
MeSH terms
Bacterial InfectionsGene Expression RegulationHumansImmunologic MemoryLymphocyte ActivationNeoplasmsT-Lymphocytes, CytotoxicTranscription, GeneticVirus DiseasesSignal TransductionCytokinesClonal AnergyCD57 AntigensT-Lymphocytes, Regulatory
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References
Regulation of type I interferon responses
Nature reviews. Immunology · 2013 · 3,197 citations
PD‐1 signaling in primary T cells
Immunological Reviews · 2009 · 762 citations
Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
Immunity · 2007 · 2,096 citations
The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
Nature Immunology · 2007 · 1,501 citations
The blockade of immune checkpoints in cancer immunotherapy
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Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
Nature Immunology · 2008 · 2,037 citations
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
The Journal of Experimental Medicine · 2010 · 2,039 citations
T cell exhaustion
Nature Immunology · 2011 · 3,925 citations
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