review Open AccessTop 1% cited

The blockade of immune checkpoints in cancer immunotherapy

Nature reviews. Cancer · 2012 · Vol. 12(4) · pp. 252–264

Drew M. Pardoll✉(Sidney Kimmel Comprehensive Cancer Center)

Cancer Immunotherapy and Biomarkers Immune Cell Function and Interaction CAR-T cell therapy researchImmune systemImmunotherapyImmune checkpointImmunologyAntigenBlockadeBiologyCancer immunotherapyImmunityCytotoxic T cell

MeSH terms

AnimalsAntigens, NeoplasmClinical Trials as TopicHumansImmunotherapyNeoplasmsTumor EscapeCancer VaccinesMolecular Targeted TherapyCTLA-4 AntigenProgrammed Cell Death 1 Receptor

Funding

Melanoma Research Alliance
Hussman Foundation

Citations

13,550

FWCI

190.50

field-weighted impact

References

129

Percentile

100%

vs. same field & year

Citations per year

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References

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Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates

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Tumor antigen–specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired

Blood · 2009 · 1,751 citations

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

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Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses

Immunity · 2007 · 1,731 citations

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