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Nitric oxide synthases in mammals
Biochemical Journal · 1994 · Vol. 298(2) · pp. 249–258
Richard G. Knowles✉(Wellcome Trust)Salvador Moncada(Wellcome Trust)
Abstract
Arginine NO-hydroxylase N&-Hydroxyarginine mono-oxygenase NADPH diaphorase Cytochrome c reductase NADPH oxidase 5 Dihydropteridine reductase Arg + NADPH + H+ + 02 -+ HydroxyArg + NADP+ + H20 HydroxyArg + 1(NADPH + H+) + 02 -+ Cit + NO + H20 NitroBlue Tetrazolium (NBT) + NADPH + H+ Reduced NBT + NADP+ Cyt c+ NADPH + H+ -+ Reduced cyt c+ NADP+ NADPH + H+ + 02 H202 + NADP+ 1NADPH + 02 -+ 02 + 1(NADP+
Nitric Oxide and Endothelin EffectsEicosanoids and Hypertension PharmacologyRenin-Angiotensin System StudiesIconCitationDownloadWorld Wide WebInformation retrievalComputer scienceLibrary scienceProgramming language
MeSH terms
Amino Acid OxidoreductasesAnimalsCalciumChromosome MappingEndothelium, VascularEnzyme InductionHumansIsoenzymesMammalsNeuronsNitric Oxide Synthase
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References
Nitric oxide synthases in mammals
Biochemical Journal · 1994 · 2,754 citations
Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate
Biochemistry · 1988 · 1,608 citations
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Analytical Biochemistry · 1982 · 11,976 citations
L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation
Biochemical and Biophysical Research Communications · 1988 · 1,347 citations
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Nature · 1987 · 10,729 citations
Isoforms of nitric oxide synthase Characterization and purification from different cell types
Biochemical Pharmacology · 1991 · 821 citations
Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction.
Journal of Histochemistry & Cytochemistry · 1992 · 618 citations
Inhibition of nitric oxide synthesis by methylene blue
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