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The molecular portraits of breast tumors are conserved across microarray platforms

BMC Genomics · 2006 · Vol. 7(1) · pp. 96–96

Zhiyuan Hu✉(UNC Lineberger Comprehensive Cancer Center)Cheng Fan(University of North Carolina at Chapel Hill)Daniel Oh(UNC Lineberger Comprehensive Cancer Center)J. S. Marron(University of North Carolina at Chapel Hill)Xiaping He(UNC Lineberger Comprehensive Cancer Center)Bahjat F. Qaqish(University of North Carolina at Chapel Hill)Chad Livasy(University of North Carolina at Chapel Hill)Lisa A. Carey(University of North Carolina at Chapel Hill)Evangeline Reynolds(University of North Carolina at Chapel Hill)Lynn G. Dressler(University of North Carolina at Chapel Hill)Andrew B. Nobel(University of North Carolina at Chapel Hill)Joel S. ParkerMatthew G. Ewend(University of North Carolina at Chapel Hill)Lynda Sawyer(University of North Carolina at Chapel Hill)Junyuan Wu(University of North Carolina at Chapel Hill)Yudong Liu(UNC Lineberger Comprehensive Cancer Center)Rita Nanda(University of Chicago)Maria Tretiakova(University of Chicago)Alejandra Ruiz Orrico(Thomas Jefferson University)Donna Dreher(Thomas Jefferson University)Juan Palazzo(Thomas Jefferson University)Laurent Perreard(ARUP Laboratories (United States))Edward William Nelson(University of Utah)Mary C. Mone(University of Utah)Heidi J. Hansen(University of Utah)Michael E. Mullins(University of Utah)John F. Quackenbush(University of Utah)Matthew J. Ellis(Washington University in St. Louis)Olufunmilayo I. Olopade(University of Chicago)Philip S. Bernard(University of Utah)Charles M. Perou(UNC Lineberger Comprehensive Cancer Center)

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Abstract

This study validates the "breast tumor intrinsic" subtype classification as an objective means of tumor classification that should be translated into a clinical assay for further retrospective and prospective validation. In addition, our method of combining existing data sets can be used to robustly validate the potential clinical value of any new gene expression profile.

Gene expression and cancer classification Molecular Biology Techniques and Applications AI in cancer detectionBreast cancerDNA microarrayBiologyData setGene expression profilingMicroarray analysis techniquesComputational biologyGeneComputer scienceBioinformatics

MeSH terms

Breast NeoplasmsFemaleHumansPredictive Value of TestsResearch DesignReproducibility of ResultsGene Expression Regulation, NeoplasticCluster AnalysisSurvival AnalysisConserved SequenceSample SizeGenetic Predisposition to DiseaseOligonucleotide Array Sequence AnalysisGenes, Neoplasm