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Gordon J. Freeman

Dana-Farber Cancer InstituteORCID https://orcid.org/0000-0002-7210-5616
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Top Publications

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response
Nature Medicine20185,444 citations
PD-1 and Its Ligands in Tolerance and Immunity
Annual Review of Immunology20085,272 citations
THE B7 FAMILY REVISITED
Annual Review of Immunology20052,279 citations
CTLA-4 can function as a negative regulator of T cell activation
Immunity19942,184 citations
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
Nature Immunology20082,037 citations
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
The Journal of Experimental Medicine20092,023 citations
CD4+CD25high Regulatory Cells in Human Peripheral Blood
The Journal of Immunology20011,845 citations
Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses
Immunity20071,731 citations
The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
Nature Immunology20071,501 citations
<i>Fusobacterium nucleatum</i>in colorectal carcinoma tissue and patient prognosis
Gut20151,035 citations
PD-L1 Expression Is Characteristic of a Subset of Aggressive B-cell Lymphomas and Virus-Associated Malignancies
Clinical Cancer Research2013835 citations
PD-1:PD-L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL-2
European Journal of Immunology2002665 citations
Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses
European Journal of Immunology2003625 citations
<i>TIM</i> genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity
Immunological Reviews2010605 citationsFirst authorCorresponding
PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer
Cell Reports2018550 citations
Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8<sup>+</sup> T cell activation and cytolysis
European Journal of Immunology2003473 citations
Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model
Oncotarget2016326 citations