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D

Dario R. Alessi

MRC Protein Phosphorylation and Ubiquitylation UnitORCID https://orcid.org/0000-0002-2140-9185

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Publications

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Impact (2-yr)

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Top Publications

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

Journal of Biological Chemistry19953,422 citationsFirst authorCorresponding

Mechanism of activation of protein kinase B by insulin and IGF-1.

The EMBO Journal19963,023 citationsFirst authorCorresponding

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

Current Biology19972,824 citationsFirst authorCorresponding

The selectivity of protein kinase inhibitors: a further update

Biochemical Journal20072,500 citations

Metformin and reduced risk of cancer in diabetic patients

BMJ20052,356 citations

The PI3K–PDK1 connection: more than just a road to PKB

Biochemical Journal20001,590 citations

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1

The EMBO Journal20041,359 citations

Journal of Cell Science20011,069 citations

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

eLife20161,052 citations

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation

Biochemical Journal1999918 citations

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

Biochemical Journal2008884 citations