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E

Eicke Latz

University of Massachusetts Chan Medical SchoolORCID https://orcid.org/0000-0003-1488-5666

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Publications

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Citations

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Impact (2-yr)

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Top Publications

Neuroinflammation in Alzheimer's disease

The Lancet Neurology20155,891 citations

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Nature Immunology20082,984 citations

Activation and regulation of the inflammasomes

Nature reviews. Immunology20132,842 citationsFirst authorCorresponding

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

The Journal of Immunology20092,835 citations

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Nature Medicine20152,700 citations

IKKε and TBK1 are essential components of the IRF3 signaling pathway

Nature Immunology20032,672 citations

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Nature Immunology20082,375 citations

Defining trained immunity and its role in health and disease

Nature reviews. Immunology20202,374 citations

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

Immunity20142,133 citations

Targeting the NLRP3 inflammasome in inflammatory diseases

Nature Reviews Drug Discovery20181,836 citations

IFI16 is an innate immune sensor for intracellular DNA

Nature Immunology20101,616 citations

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

Nature Immunology20041,343 citationsFirst authorCorresponding

Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

Nature Immunology20071,340 citations

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

Nature Immunology20101,284 citations