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Nonalcoholic Fatty Liver Disease (NAFLD) Activity Score and the Histopathologic Diagnosis in NAFLD: Distinct Clinicopathologic Meanings §Δ
Hepatology · 2010 · Vol. 53(3) · pp. 810–820
Elizabeth M. Brunt✉(Washington University in St. Louis)David E. Kleiner(National Cancer Institute)Laura Wilson(Johns Hopkins University)Patricia Belt(Johns Hopkins University)Brent A. Neuschwander‐Tetri(Saint Louis University)
Abstract
The diagnosis of definite SH or the absence of SH based on evaluation of patterns as well as individual lesions on liver biopsies does not always correlate with threshold values of the semiquantitative NAS. Clinical trials and observational studies should take these different performance characteristics into account.
Liver Disease Diagnosis and TreatmentLiver Diseases and ImmunityHepatitis B Virus StudiesNonalcoholic fatty liver diseaseInternal medicineGastroenterologyMedicineFatty liverDiseasePathology
MeSH terms
AdolescentAdultAgedAlanine TransaminaseAspartate AminotransferasesBiopsyFatty LiverFemaleHumansLiverMaleMiddle AgedProspective StudiesSensitivity and SpecificitySeverity of Illness Index
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Child Health and Human Development
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1,211
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References
Design and validation of a histological scoring system for nonalcoholic fatty liver disease†
Hepatology · 2005 · 10,531 citations
Summary of the Second Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
JAMA · 1993 · 27,890 citations
Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage
American Journal of Physiology-Endocrinology and Metabolism · 2007 · 1,651 citations
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