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Nonalcoholic Fatty Liver Disease (NAFLD) Activity Score and the Histopathologic Diagnosis in NAFLD: Distinct Clinicopathologic Meanings §Δ

Hepatology · 2010 · Vol. 53(3) · pp. 810–820
Elizabeth M. BruntDavid E. KleinerLaura WilsonPatricia BeltBrent A. Neuschwander‐Tetri

Abstract

The diagnosis of definite SH or the absence of SH based on evaluation of patterns as well as individual lesions on liver biopsies does not always correlate with threshold values of the semiquantitative NAS. Clinical trials and observational studies should take these different performance characteristics into account.

Liver Disease Diagnosis and TreatmentLiver Diseases and ImmunityHepatitis B Virus StudiesNonalcoholic fatty liver diseaseInternal medicineGastroenterologyMedicineFatty liverDiseasePathology

MeSH terms

AdolescentAdultAgedAlanine TransaminaseAspartate AminotransferasesBiopsyFatty LiverFemaleHumansLiverMaleMiddle AgedProspective StudiesSensitivity and SpecificitySeverity of Illness Index

Funding

  • National Institute of Diabetes and Digestive and Kidney Diseases
  • National Institute of Child Health and Human Development
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