Haemato-biochemical variations during femur fracture repair with bone defect by bone plating in dogs along with β-tricalcium phosphate (β-TCP) as a bone graft

Abstract

Dog femur fractures involving bone defects provide therapeutic issues that call for biocompatible bone regeneration materials and efficient fixation. In this study, six canine cases treated with bone plating and ?-tricalcium phosphate (?-TCP) as a bone graft were examined for haemato-biochemical changes throughout fracture healing. Blood samples were tested for total erythrocyte count, total leukocyte count, haemoglobin, differential leukocyte profiles and biochemical indicators such calcium, phosphorus, creatinine, alanine aminotransferase and alkaline phosphatase. Haematological indicators remained within normal limits, with transitory leucocytosis and neutrophilia noted in the early postoperative days. Biochemical indices exhibited mild, non-significant variations. Serum alkaline phosphatase showed a transient increase, indicating bone repair. Calcium and phosphorus levels demonstrated their use in mineral deposition and bone remodelling. The study found that ?-tricalcium phosphate (?-TCP) is biocompatible with bone plating for femur defect repair, resulting in stable systemic health and successful fracture healing.