Advancements in Liposomal Drug Delivery Systems for Enhancing Bioavailability of Poorly Soluble Drugs

Abstract

Liposomal drug delivery systems have emerged as promising solutions for addressing the persistent challenge of poor solubility in many therapeutic agents. By encapsulating poorly soluble drugs within lipid-based vesicles, these systems offer the potential to improve bioavailability and therapeutic efficacy. This paper examines the scientific principles underlying liposomal formulations, explores strategies for optimizing liposome design, and analyze their impact on enhancing drug absorption. Additionally, the work discusses characterization methods, regulatory elements, and key manufacturing considerations essential for successful application. The concluding sections offer perspectives on future trends and highlight ongoing advances that may further refine the capability of liposomal carriers in pharmaceutical development.