Assessment of liver function enzymes and inflammatory cytokines in non-alcoholic fatty liver disease patients

Abstract

Can liver enzyme patterns predict the inflammatory burden in patients with fatty liver disease? Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver condition worldwide, yet the relationship between hepatocellular injury markers and systemic inflammation remains incompletely characterized. This cross-sectional research evaluated liver function enzymes and inflammatory cytokines in 142 NAFLD patients compared with 78 healthy controls at Wellington Institute of Medical Sciences between April 2022 and September 2023. NAFLD patients demonstrated markedly elevated aminotransferases (ALT: 64.7±28.3 vs. 24.1±8.6 U/L; AST: 52.4±21.7 vs. 22.3±6.4 U/L, both p