Comparing the efficacy of placental extract & betamethasone with hyaluronidase in stage 2 OSMF patients of Arunachal Pradesh

Abstract

Objective: To compare the efficacy of Placental Extract vs. Betamethasone with Hyaluronidase in improving mouth opening among Stage 2 Oral Submucous Fibrosis (OSMF) patients from Arunachal Pradesh. Study Design: Twenty patients were divided into two equal groups and received biweekly intralesional injections of either Placental extract or Betamethasone with Hyaluronidase for a total of 24 sessions. Results: Significant increase in mouth opening, evaluated at baseline and after each injection, with statistical analysis showing significant improvement in both groups but no statistically significant difference between them. Conclusion: Both the Placental extract and Betamethasone with Hyaluronidase are safe and effective options for Stage 2 OSMF management in this population