Cell homing in regenerative endodontic procedures for adult mature permanent necrotic teeth: A narrative review

Abstract

Regenerative Endodontic Procedure (REP) aims to restore damaged teeth and the vitality of the teeth by biological obturation [pulp like tissue], especially in immature permanent teeth with thin roots, and it has shown successful outcome in restoring the vitality in mature permanent teeth that are associated with periapical periodontitis or periapical lesion, unlike traditional root canal treatments that fill the canal with gutta-percha. This Review is supported by studies showing tissue healing in sterile conditions. REP is now favored over apexification, which stops root development and weakens teeth.