Phytochemical profiling and evaluation of antioxidant and antidiabetic potential of Helicteres isora L. extracts

Abstract

The present study investigates the phytochemical profiling and evaluates the antioxidant and antidiabetic potential of Helicteres isora L. extracts using various in vitro assays. Qualitative and quantitative phytochemical screening revealed the presence of bioactive compounds such as alkaloids, flavonoids, tannins, phenolics, and saponins, which are known to contribute to therapeutic effects. The antioxidant activity was assessed using DPPH and ABTS radical scavenging assays, demonstrating significant free radical inhibition. The antidiabetic potential was evaluated through α-amylase and α-glucosidase inhibition studies, indicating promising enzyme inhibitory activity comparable to standard drugs. These findings suggest that Helicteres isora L. possesses potent natural antioxidant and antidiabetic properties, attributed to its rich phytochemical composition. The study supports the traditional medicinal use of this plant and provides a scientific basis for its potential application in the development of herbal therapeutics.