Development and evaluation of a liposomal gel containing Ajuga bracteosa for topical treatment of gout

Abstract

This study evaluates a liposomal gel containing Ajuga bracteosa leaf extract for the topical treatment of gout and inflammation. The extract was encapsulated using the thin-film hydration method and incorporated into a carbopol gel base. The formulation was assessed for physicochemical properties, drug release, and anti-inflammatory activity using the carrageenan-induced paw edema model in rats. The liposomal gel significantly reduced paw edema, joint swelling, and pain compared to controls, indicating improved bioavailability and therapeutic potential. This suggests it may offer a promising herbal alternative for localized gout and inflammation management.