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A study on the ameliorative effects of goldenseal, goat's rue extracts, and berberine on glucose uptake compared to metformin in a cellular model
Journal of Pharmacognosy and Phytochemistry · 2025 · Vol. 14(1) · pp. 398–409
Abstract
This study examines the effects of goat's rue (Galega officinalis L.), goldenseal (Hydrastis canadensis L.) leaves, root extracts, and berberine on glucose uptake in HepG2 cells. These plant compounds, traditionally used to alleviate diabetes symptoms, were compared to metformin. Glucose uptake was assessed using 2-NBDG, MTT assays for cytotoxicity, Bradford protein assays, and western blotting for GLUT-1 expression. Goldenseal and berberine significantly increased glucose uptake compared to metformin (p
Berberine and alkaloids researchPhytochemistry and biological activities of Ficus speciesFood Science and Nutritional StudiesBerberineMetforminTraditional medicineChemistryDiabetes mellitusBotanyPharmacologyBiologyMedicineEndocrinology
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