Study on the cytochrome B protein of Culex quinquefasciatus with Malic acid using automated Insilico docking protocols

Abstract

Culex quinquefasciatus is a major threat faced by people in India. The nematode worm, Wuchereria bancrofti causes Lymphatic filariasis which is transmitted by Culex quinquefasciatus acting as a vector. The aim of the present Insilico research work is to validate how malic acid interacts with the protein of the mosquito species, Culex quinquefasciatus using Bioinformatic tools. The target protein molecule is Cytochrome b mitochondrion protein of the mosquito species. The structure of Malic acid is retrieved from the generalized database, NCBI (National Center for Biotechnology Information). Drug docking studies are performed using an automated drug docking server. The chemical molecule is converted from 2D to 3D using an advanced molecular visualization software. The result obtained from docking clearly shows that Malic acid binds with the functional domain region of Cytochrome b protein of the mosquito sps. All the results were clearly elucidated using 3D visualization techniques on the binding interaction between malic acid and the protein of the mosquito sps. It was thus proved that Malic acid is an efficient agent for controlling Culex quinquefasciatus.