To investigate the link between serum prolactin levels and the severity of liver cirrhosis

Abstract

Aim: To investigate the link between serum prolactin levels and the severity of liver cirrhosis. Methods: This cross-sectional research covers 60 chronic liver disease patients (CLD). There are 25 female patients and 35 male patients. Their ages vary from 35 to 58 years, with a mean standard deviation of 52.94±6.99. According to the Modified Child's Pugh score, the cases studied are divided into three groups: Group 1: Consists of 20 individuals with mild liver cirrhosis. Group 2: Consists of 20 individuals with mild liver cirrhosis. Group 3: Consists of 20 individuals with severe liver cirrhosis. Results: This research included 60 patients ranging in age from 35 to 60 years old, with a mean SD of 52.94±6.99 years; there were 35 male patients (58.33 percent) and 25 female patients (41.67 percent). PRL levels range from (5.6-39) ng/ml with a mean S.D of (19.76±10.14 ng/dl). The albumin level ranges from (1.3-4.2) mgdl, with a mean S.D of (3.18±0.95) gdl. Total bilirubin levels range from (1.3-6.8) mg/dl, with a mean standard deviation of (2.71.4 mg/dl). The prothrombin time ranges from (2.8-8.5) sec, with a mean S.D of (8.85.44 sec). Creatinine levels range from (0.7-6) mg/dl, with a mean S.D. of (2.35±1.31 mg/dl). The ultrasonic diameter of the portal vein (PV) varies from (10-19) cm with a mean S.D (13.19±1.84 cm). The child Pugh score ranges from (5 to 14) with a mean S.D of (10.16±4.16). The Roc curve for blood prolactin level as a predictor of severe/moderate liver cirrhosis reveals that at the cutoff point of 19.8 ng/ml, the sensitivity is 68.94%, the specificity is 80.15%, the PPV is 85.5%, and the NPV is 62%. Conclusion: Prolactin levels rise considerably in individuals with severe liver illness, especially those with ascites and hepatic encephalopathy. A high prolactin level might therefore be regarded as a risk factor for liver cirrhosis.