articleTop 1% cited
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
Advanced Drug Delivery Reviews · 1997 · Vol. 23(1-3) · pp. 3–25
Christopher A. Lipinski✉(Pfizer (United States))Franco Lombardo(Pfizer (United States))Beryl W. Dominy(Pfizer (United States))Paul J. Feeney(Pfizer (United States))
Crystallization and Solubility StudiesAnalytical Chemistry and ChromatographyComputational Drug Discovery MethodsSolubilityDrug discoveryChemistryThermodynamicsPermeability (electromagnetism)Hildebrand solubility parameterPermeationWork (physics)Computational chemistryOrganic chemistry
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References
Comparison of Reliability of log P Values for Drugs Calculated by Several Methods.
Chemical and Pharmaceutical Bulletin · 1994 · 276 citations
Solubility and partitioning I: Solubility of nonelectrolytes in water
Journal of Pharmaceutical Sciences · 1980 · 570 citations
Hydrogen Bonding. 32. An Analysis of Water-Octanol and Water-Alkane Partitioning and the Δlog P Parameter of Seiler
Journal of Pharmaceutical Sciences · 1994 · 759 citations
Scales of solute hydrogen-bonding: their construction and application to physicochemical and biochemical processes
Chemical Society Reviews · 1993 · 2,105 citations
Simple Method of Calculating Octanol/Water Partition Coefficient.
Chemical and Pharmaceutical Bulletin · 1992 · 523 citations
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