To determine the correlation between HbA1c and AIP in patients diagnosed with type 2 diabetes mellitus

Abstract

Aim: to assess the lipid patterns and association of AIP with HbA1c in diabetes patients.Methods: This study conducted in the Department of Medicine, Metro Hospital and Cancer Research Centre, Jabalpur, MP, India from October 2018 to January 2020. Total 160 diagnosed cases of DM type 2 in the age group of 20-70 years were included in this study. The patients were divided into 2 groups depending on the levels of glycated hemoglobin. Venous blood samples from all the subjects were collected after at least 6 hours fasting and analyzed for fasting plasma glucose (FPG), 2 hours post prandial glucose levels(2hPG), serum total cholesterol (TC), triglycerides (TG), HDL-C, Very low density lipoprotein cholesterol (VLDL-C) & LDL-C analysis was done by standard methods. The atherogenic index of plasma (AIP) was calculated by the formula base 10 logarithm of the ratio of TG to HDL-C.Results: Out of the 160 patients studied, there were 70 males and 90 females. The maximum number of patients was in the age group of 50-60 years. The levels of FBG, TC, TG,VLDL-C LDL-C, HbA1c, AIP, ratios of TC/HDL-C and LDL-C/HDL-C are increased, while the levels of HDL-C are decreased in patients with HbA1c >7% as compared to patients with HbA1c ≤ 7% and these values are highly significant. The patients with HbA1c >7% had dyslipidemia as the most prominent feature in the lipid profile. Direct and significant correlation of HbA1c with FBG, 2Hpg was found.Conclusion: It can be concluded from the present study that patients with poor glycaemic control have a atherogenic lipid profile and Glycated haemoglobin predicts dyslipidemia and atherogenicity.