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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

New England Journal of Medicine · 2020 · Vol. 383(27) · pp. 2603–2615

Fernando P. Polack✉(SUNY Upstate Medical University)Stephen J. Thomas(Johns Hopkins University)Nicholas Kitchin(Institut de Recherche Vaccinale)Judith Absalon(Johns Hopkins University)Alejandra Gurtman(Institut de Recherche Vaccinale)Stephen Lockhart(Institut de Recherche Vaccinale)John L. Perez(Johns Hopkins University)Gonzalo Pérez Marc(SUNY Upstate Medical University)Edson Duarte Moreira(SUNY Upstate Medical University)Cristiano A. F. Zerbini(Institut de Recherche Vaccinale)Ruth Bailey(Johns Hopkins University)Kena A. Swanson(Johns Hopkins University)Satrajit Roychoudhury(SUNY Upstate Medical University)Kenneth Koury(SUNY Upstate Medical University)Ping Li(SUNY Upstate Medical University)Warren V. Kalina(SUNY Upstate Medical University)David Cooper(SUNY Upstate Medical University)Robert W. Frenck(Institut de Recherche Vaccinale)Laura L Hammitt(Johns Hopkins University)Özlem Türeci(Institut de Recherche Vaccinale)Haylene Nell(Johns Hopkins University)Axel Schaefer(SUNY Upstate Medical University)Serhat Ünal(Institut de Recherche Vaccinale)Dina B Tresnan(Institut de Recherche Vaccinale)Susan Mather(Institut de Recherche Vaccinale)Philip R. Dormitzer(Johns Hopkins University)Uğur Şahin(SUNY Upstate Medical University)Kathrin U. Jansen(SUNY Upstate Medical University)William C. Gruber(SUNY Upstate Medical University)

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Abstract

A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older. Safety over a median of 2 months was similar to that of other viral vaccines. (Funded by BioNTech and Pfizer; ClinicalTrials.gov number, NCT04368728.).

SARS-CoV-2 and COVID-19 Research Viral gastroenteritis research and epidemiology Viral Infections and Immunology ResearchCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakVirologyBusinessMedicineOutbreakInternal medicineInfectious disease (medical specialty)