A metastatic neuroendocrine small cell carcinoma of the gall bladder: case report and a comprehensive review of the literatures

Abstract

Primary neuroendocrine small cell carcinoma (SCC) of the gallbladder (GB) is a rare, aggressive malignancy accounting for less than 1% of all GB tumours. With a high propensity for extensive local invasion and early metastasis, the disease carries a poor prognosis without prompt intervention. Definitive diagnosis requires histopathological examination (HPE) with immunohistochemistry (IHC). Here, we report a metastatic case of SCC-GB and review the literature of metastatic SCC GB.