Anti-leishmanial activities of some compounds of Tarchonanthus camphoratus leaf surface exudates

Abstract

One sesquiterpene, (-​)​-​parthenolide (1), and four known methoxylated flavonoids; 5,7,3´,4´-tetrahydroxy-3-methoxyflavone (2), 5,7,4´-trihydroxy-6-methoxyflavone (3), 5,7,3´,4´-tetrahydroxy-6-methoxyflavone (4) and 5-hydroxy-7,8-dimethoxyflavanone (5) were characterized from leaf surface exudates of Tarchonanthus camphoratus. The structures of the compounds were determined based on spectroscopic data analyses. Compound 2 exhibited moderate anti-leishmanial activities against Leishmania donovani with IC50 value of 12.84 µg/mL. (vs 0.85 for pentamidine and 0.12 µg/mL for amphotericin B). Compound 4 and 5 also showed anti-leishmanial activities with IC50 values of 26.24 and 23.15 µg/mL respectively. All compounds tested were not cytotoxic at 5 µg/mL.