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Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts

The Lancet Neurology · 2020 · Vol. 19(5) · pp. 422–433

Thomas K. Karikari(University of Gothenburg)Tharick A. Pascoal(Montreal Neurological Institute and Hospital)Nicholas J. Ashton(University of Gothenburg)Shorena Janelidze(Lund University)Andréa Lessa Benedet(McGill University)Juan Lantero‐Rodriguez(University of Gothenburg)Mira Chamoun(McGill University)Mélissa Savard(McGill University)Min Su Kang(McGill University)Joseph Therriault(McGill University)Michael Schöll(University of Gothenburg)Gassan Massarweh(Montreal Neurological Institute and Hospital)Jean-Paul Soucy(Montreal Neurological Institute and Hospital)Kina Höglund(University of Gothenburg)Gunnar Brinkmalm(University of Gothenburg)Niklas Mattsson(Skåne University Hospital)Sebastian Palmqvist(Lund University)Serge Gauthier(McGill University)Erik Stomrud(Lund University)Henrik Zetterberg(University of Gothenburg)Oskar Hansson(Skåne University Hospital)Pedro Rosa‐Neto(McGill University)Kaj Blennow✉(Sahlgrenska University Hospital)

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Dementia and Cognitive Impairment Research Alzheimer's disease research and treatments Functional Brain Connectivity StudiesMedicineBiomarkerCohortDementiaProspective cohort studyInternal medicineOncologyDiseaseCohort studyCognitive decline

MeSH terms

AgedAged, 80 and overAdultAlzheimer DiseaseFemaleHumansMaleMiddle AgedModels, TheoreticalPhosphorylationProspective StudiesBiomarkerstau ProteinsYoung AdultCognitive Dysfunction

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Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology