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Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization

Cardiovascular Research · 2019 · Vol. 115(7) · pp. 1205–1216

Jinxuan Zhao(Nanjing Drum Tower Hospital)Xueling Li(Hangzhou Medical College)Jiaxin Hu(Nanjing Drum Tower Hospital)Fu Chen(Nanjing Drum Tower Hospital)Shuaihua Qiao(Nanjing Drum Tower Hospital)Xuan Sun(Nanjing Drum Tower Hospital)Ling Gao(Nanjing Drum Tower Hospital)Jun Xie✉(Nanjing Drum Tower Hospital)Biao Xu✉(Nanjing Drum Tower Hospital)

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Abstract

Our data indicate that MSC-Exo attenuates myocardial I/R injury in mice via shuttling miR-182 that modifies the polarization status of macrophages. This study sheds new light on the application of MSC-Exo as a potential therapeutic tool for myocardial I/R injury.

Extracellular vesicles in disease Tissue Engineering and Regenerative Medicine Cardiac Structural Anomalies and RepairMesenchymal stem cellMicrovesiclesMacrophage polarizationInflammationTLR4MacrophageMedicineReperfusion injuryExosomeStromal cell

MeSH terms

Cell PlasticityAnimalsCells, CulturedDisease Models, AnimalGene Expression RegulationMacrophagesMaleMice, Inbred BALB CMice, Inbred C57BLMyocardial InfarctionMyocardiumPhenotypeSignal TransductionMyocardial Reperfusion InjuryMice, Knockout