article Open AccessTop 1% cited
Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes
Immunity · 2018 · Vol. 50(1) · pp. 253–271.e6
Timothy R. Hammond(Broad Institute)Connor Dufort(Boston Children's Hospital)Lasse Dissing‐Olesen(Harvard University)Stefanie Giera(Harvard University)Adam M. H. Young(Medical Research Council)Alec Wysoker(Broad Institute)Alec J. Walker(Broad Institute)Frederick W. Gergits(Boston Children's Hospital)Michael Segel(Wellcome/MRC Cambridge Stem Cell Institute)James Nemesh(Broad Institute)Samuel E. Marsh(Harvard University)Arpiar Saunders(Harvard University)Evan Z. Macosko(Broad Institute)Florent Ginhoux(Singapore Immunology Network)Jinmiao Chen(Agency for Science, Technology and Research)Robin J.M. Franklin(Wellcome/MRC Cambridge Stem Cell Institute)Xianhua Piao(Harvard University)Steven A. McCarroll✉(Broad Institute)Beth Stevens✉(Howard Hughes Medical Institute)
Neuroinflammation and Neurodegeneration MechanismsImmune cells in cancerImmune Response and InflammationMicrogliaBiologyMultiple sclerosisChemokineImmune systemCellInflammationNeuroscienceCentral nervous systemRNA
MeSH terms
Adaptation, PhysiologicalAgingAnimalsBrainBrain InjuriesCell DifferentiationDemyelinating DiseasesHumansLongevityMice, Inbred C57BLMultiple SclerosisSequence Analysis, RNAMicrogliaMiceSingle-Cell Analysis
Funding
- International Rett Syndrome Foundation
- Stanley Center for Psychiatric Research, Broad Institute
- Medical Research Council
Citations
2,265
FWCI
76.79
field-weighted impact
References
73
Percentile
100%
vs. same field & year
Citations per year
Cited by
Microglia: Agents of the CNS Pro-Inflammatory Response
Cells · 2020 · 348 citations
The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques
Cell Reports · 2019 · 950 citations
Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy
Frontiers in Neuroscience · 2021 · 532 citations
Microglia Heterogeneity in the Single-Cell Era
Cell Reports · 2020 · 774 citations
Microglia states and nomenclature: A field at its crossroads
Neuron · 2022 · 1,742 citations
References
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
Nature Neuroscience · 2013 · 1,702 citations
Macrophage migration inhibitory factor: a regulator of innate immunity
Nature reviews. Immunology · 2003 · 1,776 citations
Glutamate neurotoxicity and diseases of the nervous system
Neuron · 1988 · 8,002 citations
Blood-Brain Barrier Breakdown in the Aging Human Hippocampus
Neuron · 2015 · 2,011 citations
Microglia Modulate Wiring of the Embryonic Forebrain
Cell Reports · 2014 · 663 citations
Spatial reconstruction of single-cell gene expression data
Nature Biotechnology · 2015 · 7,447 citations
Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets
Cell · 2015 · 7,706 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.