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Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: An update on glucose toxicity

Biomedicine & Pharmacotherapy · 2018 · Vol. 107 · pp. 306–328
Biplab GiriSananda DeyTanaya DasMrinmoy SarkarJhimli BanerjeeSandeep Kumar Dash
Advanced Glycation End Products researchNatural Antidiabetic Agents StudiesMetabolism, Diabetes, and CancerDiabetes mellitusGlycationMedicinePathophysiologyPolyol pathwayOxidative stressInsulin resistanceEndocrinologyCancerInternal medicine

MeSH terms

AnimalsChronic DiseaseCommunicable DiseasesGlucoseHumansHyperglycemiaModels, BiologicalMultiple Organ FailureNeoplasms

Funding

  • Department of Science and Technology, Ministry of Science and Technology, India
  • Science and Engineering Research Board
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References
Islet   cell failure in type 2 diabetes
Journal of Clinical Investigation · 2006 · 1,643 citations
Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction
American Journal of Physiology-Endocrinology and Metabolism · 1991 · 563 citations
Diabetes and mitochondrial function: Role of hyperglycemia and oxidative stress
Toxicology and Applied Pharmacology · 2006 · 998 citations
Oxidative stress: the vulnerable β-cell
Biochemical Society Transactions · 2008 · 516 citations
Obesity is associated with macrophage accumulation in adipose tissue
Journal of Clinical Investigation · 2003 · 8,580 citations
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