article Open AccessTop 1% cited

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification

Cell stem cell · 2017 · Vol. 22(2) · pp. 191–205.e9

Hengyou Weng✉(University of Cincinnati)Huilin Huang(University of Cincinnati)Huizhe Wu(University of Cincinnati)Xi Qin(University of Cincinnati)Boxuan Zhao(Howard Hughes Medical Institute)Lei Dong(University of Cincinnati)Hailing Shi(Howard Hughes Medical Institute)Jennifer R. Skibbe(University of Cincinnati)Chao Shen(University of Cincinnati)Chao Hu(Zhejiang Cancer Hospital)Yue Sheng(University of Illinois Chicago)Yungui Wang(Zhejiang Cancer Hospital)Mark Wunderlich(Cincinnati Children's Hospital Medical Center)Bin Zhang(City of Hope)Louis C. Doré(Howard Hughes Medical Institute)Rui Su(University of Cincinnati)Xiaolan Deng(University of Cincinnati)Kyle Ferchen(University of Cincinnati)Chenying Li(Zhejiang Cancer Hospital)Miao Sun(Cincinnati Children's Hospital Medical Center)Zhike Lu(Howard Hughes Medical Institute)Xi Jiang(University of Cincinnati)Guido Marcucci(City of Hope)James C. Mulloy(Cincinnati Children's Hospital Medical Center)Jianhua Yang(Sun Yat-sen University)Zhijian Qian(University of Illinois Chicago)Minjie Wei(China Medical University)Chuan He(Howard Hughes Medical Institute)Jianjun Chen(University of Cincinnati)

View via DOI Full-text PDF

RNA modifications and cancer Cancer-related gene regulation Cancer-related molecular mechanisms researchBiologyHaematopoiesisMyelopoiesisProgenitor cellCell biologyStem cellMyeloid leukemiaMyeloidCancer researchGene silencing

MeSH terms

Proto-Oncogene Protein Spi-1AdenosineAnimalsCell DifferentiationCell SurvivalHematopoietic Stem CellsHumansMethyltransferasesMice, Inbred C57BLProto-Oncogene ProteinsRNA, MessengerProtein BiosynthesisNeoplastic Stem CellsLeukemia, Myeloid, AcuteTrans-Activators