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Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease

Circulation Research · 2017 · Vol. 122(3) · pp. 433–443
Pim van der Harst✉Niek Verweij
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Abstract

We identified 64 novel genetic risk loci for CAD and performed fine mapping of all 161 risk loci to obtain a credible set of causal variants. The large expansion of reconstituted gene sets argues in favor of an expanded omnigenic model view on the genetic architecture of CAD.

Genetic Associations and EpidemiologyRNA modifications and cancerNuclear Receptors and SignalingBiobankGenetic architectureGeneticsBiologyGenome-wide association studyCoronary artery diseaseGenomeIdentification (biology)Genetic associationComputational biology

MeSH terms

Atrial FibrillationChromatinCoronary Artery DiseaseEnhancer Elements, GeneticGene Expression RegulationHeart FailureHumansCausalityCase-Control StudiesMutation, Missense3' Untranslated RegionsPolymorphism, Single NucleotideQuantitative Trait LociGenome-Wide Association Study

Funding

  • Rijksuniversiteit Groningen
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek
  • Center for Information Technology
Citations
1,227
FWCI
66.28
field-weighted impact
References
44
Percentile
100%
vs. same field & year
Citations per year
References
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