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A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate. Report from the Committee of Principal Investigators.

Heart · 1978 · Vol. 40(10) · pp. 1069–1118

M. F. Oliver✉(World Health Organization)J. A. Heady(World Health Organization)J Morris(World Health Organization)Jane Cooper(Clinical Trial Investigators)H Geizerová(World Health Organization)M Czukas(World Health Organization)J. Duba(World Health Organization)Erika Östör(Institute of Clinical and Experimental Medicine)I Gyárfás(Institute of Clinical and Experimental Medicine)Gudrun Lamm(Institute of Clinical and Experimental Medicine)K Green(Institute of Clinical and Experimental Medicine)Z Písa(World Health Organization)Kazuki Uemura(World Health Organization)G Heady(Clinical Trial Investigators)P ArmitageD BarnettJ CraigD RobinsonPerenna RogersMA BarrettJ ThorpD BerkowitzH BlackburnA KeysE SimonsonP RantaharjuS PunsarN BreslowD BrownS KinchJ DoyleL CarlsonL B6ttigerJ CooperH GeizerovaM OliverD CoxS DaytonM PearceS HashimotoW DixonU TomiyasuH DewarM OliverF EdererP LerenO TurpeinenI FrantzJrK EinarssonK HellstromB LeijdS EngerV JohnsenA SamuelsenE LawsA FeinsteinD FredericksonR LevyR LeesS GrundyE AhrensG SalenB SchreibmanP NestelM HalperinJ CornfieldS MitchellJ HeadyM HillM HillB DrasarR WilliamsT MeadeA CoxJ SimpsonB MorsonW KannelT DawberG FriedmanW GlennonP MacnamaraW KannelJ DoyleP MacnamaraP QuickentonT GordonA KeysC AravanisH BlackburnF Van BuchemR BuzinaB DjordjevikF FidanzaM KarvonenA MenottiV PudduH TaylorL KrasnoG KideraB LeijdB AngelinK EinarssonE LithellJ BobergH HedstrandK HellsingS LjunghallB VessbyN MantelJ MedalieH KahnH NeufeldE RissU GoldbourtT PerlsteinD OronM MiettinenO TurpeinenM KarvonenR ElosuoE PaavilianenM OliverD PertsemlidisD PanveliwallaE AhrensJrG RoseH BlackburnR SturdevantM PearceS DaytonJ ThorpJ ThorpWaringWS WalkerD Duncan

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Abstract

A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate Report1 from the Committee of Principal Investigators SUMMARY A double-blind intervention trial was started in 1965 to test the hypothesis that the incidence of ischaemic heart disease in middle-aged men can be reduced by lowering raised serum cholesterol levels. It was carried out in 3 European centres-Edinburgh, Budapest, and Prague. Serum cholesterol was to be lowered by the drug clofibrate (ethyl chlorophenoxyisobutyrate) which was considered to be free from serious side effects.

Pharmacogenetics and Drug Metabolism Lipoproteins and Cardiovascular Health Health Systems, Economic Evaluations, Quality of LifeIschaemic heart diseaseClofibratePrincipal (computer security)MedicinePrimary preventionClinical trialDiseasePrimary (astronomy)Internal medicineCardiology

MeSH terms

AdultCardiovascular DiseasesCholelithiasisCholesterolClinical Trials as TopicClofibrateCoronary DiseaseDouble-Blind MethodHumansHypercholesterolemiaMaleMiddle AgedNeoplasmsTriglyceridesDiabetes Complications