review Open AccessTop 1% cited
Prognostic significance of tumor-associated macrophages in breast cancer: a meta-analysis of the literature
Oncotarget · 2017 · Vol. 8(18) · pp. 30576–30586
Xixi Zhao(Second Affiliated Hospital of Xi'an Jiaotong University)Jingkun Qu(First Affiliated Hospital of Xi'an Jiaotong University)Yuchen Sun(Xi'an Jiaotong University)Jizhao Wang(First Affiliated Hospital of Xi'an Jiaotong University)Xu Liu(Second Affiliated Hospital of Xi'an Jiaotong University)Feidi Wang(Second Affiliated Hospital of Xi'an Jiaotong University)Hong Zhang(Second Affiliated Hospital of Xi'an Jiaotong University)Wen Wang(Second Affiliated Hospital of Xi'an Jiaotong University)Xingcong Ma(Second Affiliated Hospital of Xi'an Jiaotong University)Xiaoyan Gao(Second Affiliated Hospital of Xi'an Jiaotong University)Shuqun Zhang✉(Second Affiliated Hospital of Xi'an Jiaotong University)
Abstract
High density of TAMs was associated with poor survival rates of breast cancer. TAMs in stroma are associated with worse outcome than that in nest and using CD68 as a biomarker for TAMs to evaluate the risk is better than CD163 or CD206 alone. Moreover, high infiltration of TAMs was significantly associated with negative hormone receptor status and malignant phenotype. TAMs infiltration can serve as a novel prognostic factor in breast cancer patients.
Immune cells in cancerInflammatory Biomarkers in Disease PrognosisCancer Cells and MetastasisMedicineBreast cancerHazard ratioOncologyInternal medicineCancerMeta-analysisProportional hazards modelOdds ratioGynecology
MeSH terms
Breast NeoplasmsCell CountFemaleHumansMacrophagesPhenotypePrognosisRecurrenceBiomarkersPublication BiasTumor MicroenvironmentNeoplasm Grading
Funding
- National Natural Science Foundation of China
Citations
338
FWCI
12.74
field-weighted impact
References
32
Percentile
99%
vs. same field & year
Citations per year
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