Safety and Efficacy of Herbal Ointment formulated with Methanolic Extract of Mikania cordata as Treatment for Acute Superficial Injury.

Abstract

The main objective of this study is to investigate the safety and efficacy of herbal ointment formulated with methanolic extract of Mikania cordata as Treatment for acute superficial injury. Ointment was prepared by fusion method using emulsifying ointment as base. The formulation was then tested for its physicochemical properties like loss of drying, pH, spreadability, extrudability, together with diffusion study and gave a satisfactory result. The prepared ointment was also stable at 40C, 250C and 370C. Further, the formulation was evaluated for its anti-bacterial activity against Staphylococcus aureus, Pseudomonas sp., Bacillus sp., by agar diffusion method by using Mupirocin (6%w/w) as a standard. The formulation showed significant (p 0.01) between those treated with M. cordata and those treated with mupirocin. Overall result of this study reveals that the herbal ointment of Mikania cordata is safe and as pharmacologically competent as Mupirocin and can be used as treatment for superficial injuries.