reviewTop 1% cited

Depression and Hypothalamic-Pituitary-Adrenal Activation: A Quantitative Summary of Four Decades of Research

Psychosomatic Medicine · 2011 · Vol. 73(2) · pp. 114–126

Cinnamon Stetler✉(Furman University)Gregory E. Miller

Abstract

The current study suggests that the degree of HPA hyperactivity can vary considerably across patient groups. Results are consistent with HPA hyperactivity as a link between depression and increased risk for conditions, such as diabetes, dementia, coronary heart disease, and osteoporosis. Such a link is strongest among older inpatients who display melancholic or psychotic features of depression.

Stress Responses and Cortisol Tryptophan and brain disorders Hormonal Regulation and HypertensionAdrenocorticotropic hormoneDepression (economics)Internal medicineMelancholic depressionPsychologyMedicineEndocrinologyMelancholiaHormone

MeSH terms

AdolescentAdrenocorticotropic HormoneAdultChildCorticotropin-Releasing HormoneDepressive DisorderFemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemMaleMiddle AgedPituitary-Adrenal SystemResearchBibliometrics

Citations

1,086

FWCI

17.57

field-weighted impact

References

Percentile

100%

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Citations per year

Cited by

Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression