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A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors
AIDS · 1998 · Vol. 12(7) · pp. F51–F58
Andrew Carr✉(St Vincent's Hospital)Katherine Samaras(Garvan Institute of Medical Research)Samantha Burton(St Vincent's Hospital Sydney)Matthew Law(UNSW Sydney)Judith Freund(St Vincent's Hospital Sydney)Donald J. Chisholm(Garvan Institute of Medical Research)David A. Cooper(National Centre for Clinical Research on Emerging Drugs)
Abstract
A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance is a common complication of HIV protease inhibitors. Diabetes mellitus is relatively uncommon.
HIV/AIDS drug development and treatmentHIV-related health complications and treatmentsHIV Research and TreatmentLipodystrophyInsulin resistanceMedicineProtease inhibitor (pharmacology)Human immunodeficiency virus (HIV)Internal medicineProteaseInsulinDiabetes mellitusEndocrinology
MeSH terms
AdultBody CompositionCross-Sectional StudiesDiabetes MellitusFemaleHumansHyperlipidemiasInsulin ResistanceLipodystrophyMaleRisk FactorsSyndromeHIV InfectionsHIV Protease InhibitorsSaquinavir
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References
THE GLUCOSE FATTY-ACID CYCLE ITS ROLE IN INSULIN SENSITIVITY AND THE METABOLIC DISTURBANCES OF DIABETES MELLITUS
The Lancet · 1963 · 5,156 citations
Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
Diabetologia · 1985 · 31,188 citations
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