review Open AccessTop 1% cited
The role of inflammation in depression: from evolutionary imperative to modern treatment target
Nature reviews. Immunology · 2015 · Vol. 16(1) · pp. 22–34
Andrew H. Miller✉(Emory University)Charles L. Raison(University of Wisconsin–Madison)
Tryptophan and brain disordersStress Responses and CortisolNeuroendocrine regulation and behaviorNeuroscienceImmune systemInflammationAntidepressantCrosstalkDepression (economics)Innate immune systemMedicineMicrogliaPsychology
MeSH terms
BrainDepressionHumansImmunity, InnateInflammationT-LymphocytesSignal TransductionCytokinesNeurotransmitter AgentsAdaptive ImmunityInflammasomes
Citations
3,580
FWCI
50.44
field-weighted impact
References
133
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100%
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Citations per year
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References
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Neuropsychopharmacology · 2002 · 781 citations
CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression
Molecular Psychiatry · 2009 · 614 citations
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PLoS Genetics · 2011 · 607 citations
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Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Biological Psychiatry · 2009 · 3,778 citations
Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications
Nature Immunology · 2014 · 1,481 citations
Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice
Molecular Psychiatry · 2008 · 1,258 citations
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