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Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome

Critical Care Medicine · 2015 · Vol. 44(2) · pp. 275–281

Bita Shakoory✉(Kulicke & Soffa (United States))Joseph A. CarcilloW. Winn Chatham(University of Alabama at Birmingham)Richard AmdurHuaqing ZhaoCharles A. Dinarello(University of Colorado Denver)Randy Q. CronSteven M. Opal(Brown University)

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Abstract

In this subgroup analysis, interleukin-1 receptor blockade was associated with significant improvement in survival of patients with sepsis and concurrent hepatobiliary dysfunction/disseminated intravascular coagulation. A prospective randomized trial using features of macrophage activation syndrome for mortality risk stratification should be undertaken to confirm the role of interleukin-1 blockage.

Sepsis Diagnosis and Treatment Inflammation biomarkers and pathways Autoimmune and Inflammatory Disorders ResearchAnakinraMedicineDisseminated intravascular coagulationSepsisInternal medicineGastroenterologyMacrophage activation syndromeOrgan dysfunctionSeptic shockSurgery

MeSH terms

AdolescentAdultAge FactorsAgedAged, 80 and overBiliary Tract DiseasesDisseminated Intravascular CoagulationDouble-Blind MethodFemaleHumansLiver DiseasesMaleMiddle AgedMultiple Organ FailureRespiratory Distress Syndrome

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