reviewTop 1% cited
Vascular Endothelial Growth Factor
Arteriosclerosis Thrombosis and Vascular Biology · 2009 · Vol. 29(6) · pp. 789–791
Napoleone Ferrara✉(Bechtel (United States))
Abstract
Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the treatment of advanced cancer and neovascular age-related macular degeneration. This brief review provides a historic account of the challenges associated with the discovery of VEGF and the early steps in elucidating the role of this molecule in the regulation of angiogenesis.
Angiogenesis and VEGF in CancerCancer, Hypoxia, and MetabolismVascular Tumors and AngiosarcomasAngiogenesisVascular endothelial growth factorRegulatorMacular degenerationVEGF receptorsVascular endothelial growth factor AMedicinePathologicalCancer researchGrowth factor
MeSH terms
AnimalsHumansNeoplasmsSignal TransductionNeovascularization, PhysiologicAngiogenesis InhibitorsReceptors, Vascular Endothelial Growth FactorVascular Endothelial Growth Factor AEndothelial CellsHistory, 20th CenturyHistory, 21st Century
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