article Open AccessTop 1% cited
10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes
New England Journal of Medicine · 2008 · Vol. 359(15) · pp. 1577–1589
Rury R. Holman✉(Oxford BioMedica (United Kingdom))Sanjoy K. Paul(Oxford Centre for Diabetes, Endocrinology and Metabolism)M. Angelyn Bethel(Diabetes Australia)David R. Matthews(Oxford Biomedical Research)H. A. W. Neil(Oxford Biomedical Research)
Abstract
Despite an early loss of glycemic differences, a continued reduction in microvascular risk and emergent risk reductions for myocardial infarction and death from any cause were observed during 10 years of post-trial follow-up. A continued benefit after metformin therapy was evident among overweight patients. (UKPDS 80; Current Controlled Trials number, ISRCTN75451837.)
Diabetes Treatment and ManagementMetabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and LipoproteinsMedicineUnited Kingdom Prospective Diabetes StudyGlycated hemoglobinMetforminType 2 diabetesInternal medicineDiabetes mellitusMyocardial infarctionSulfonylureaClinical endpoint
MeSH terms
AgedBlood GlucoseDiabetes Mellitus, Type 2Diabetic AngiopathiesFemaleFollow-Up StudiesGlycated HemoglobinHumansHypoglycemic AgentsInsulinMaleMetforminMiddle AgedMyocardial InfarctionRisk
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