review Open AccessTop 1% cited
Missing heritability and strategies for finding the underlying causes of complex disease
Nature Reviews Genetics · 2010 · Vol. 11(6) · pp. 446–450
Evan E. Eichler✉(University of Washington)Jonathan Flint(Centre for Human Genetics)Greg Gibson(Georgia Institute of Technology)Augustine Kong(deCODE Genetics (Iceland))Suzanne M. Leal(Baylor College of Medicine)Jason H. Moore(Dartmouth College)Joseph H. Nadeau(Case Western Reserve University)
Genetic Associations and EpidemiologyGenomics and Rare DiseasesNutrition, Genetics, and DiseaseMissing heritability problemHeritabilityBiologyGenetic architectureGenome-wide association studyDiseaseEvolutionary biologyGeneticsQuantitative trait locusGenetic variants
MeSH terms
DiseaseGenotypeHumansPhenotypePolymorphism, GeneticResearch DesignQuantitative Trait, HeritableGenetic Predisposition to DiseaseInheritance PatternsGenome-Wide Association Study
Citations
1,747
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90.51
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100%
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References
Finding the missing heritability of complex diseases
Nature · 2009 · 8,468 citations
A Groupwise Association Test for Rare Mutations Using a Weighted Sum Statistic
PLoS Genetics · 2009 · 1,166 citations
Methods for Detecting Associations with Rare Variants for Common Diseases: Application to Analysis of Sequence Data
The American Journal of Human Genetics · 2008 · 1,605 citations
Rare Variants Create Synthetic Genome-Wide Associations
PLoS Biology · 2010 · 866 citations
Data and Theory Point to Mainly Additive Genetic Variance for Complex Traits
PLoS Genetics · 2008 · 1,104 citations
Heritability in the genomics era — concepts and misconceptions
Nature Reviews Genetics · 2008 · 1,936 citations
Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems
Nature Reviews Genetics · 2008 · 1,635 citations
EVOLUTION IN MENDELIAN POPULATIONS
Genetics · 1931 · 8,981 citations
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