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Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer’s Disease

Journal of Pharmacology and Experimental Therapeutics · 2008 · Vol. 326(1) · pp. 196–208

Aynun N. Begum✉(University of California, Los Angeles)Mychica JonesGiselle P. LimTakashi MoriharaPeter S. KimDennis D. HeathCheryl L. RockMila A. PruittFusheng YangBeverly HudspethShuxin HuKym F. FaullBruce TeterGreg M. ColeSally A. Frautschy(University of California, Los Angeles)

View via DOI Publisher page

Curcumin's Biomedical Applications Alzheimer's disease research and treatments Neuroinflammation and Neurodegeneration MechanismsCurcuminChemistryNeuroinflammationPharmacologyInflammationNeurodegenerationOxidative stressGlutathioneNeuroprotectionAmyloid beta

MeSH terms

Alzheimer DiseaseAnimalsBiological AvailabilityCurcuminDisease Models, AnimalFemaleInflammationMaleMice, Inbred C57BLStructure-Activity RelationshipMice

Citations

596

FWCI

10.30

field-weighted impact

References

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99%

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References

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Curcumin labels amyloid pathology <i>in vivo</i> , disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model

Journal of Neurochemistry · 2007 · 650 citations

Stability of curcumin in buffer solutions and characterization of its degradation products

Journal of Pharmaceutical and Biomedical Analysis · 1997 · 1,674 citations

Inflammation and Alzheimer's disease

Neurobiology of Aging · 2000 · 4,492 citations

The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse

Journal of Neuroscience · 2001 · 1,514 citations

Phase I Clinical Trial of Oral Curcumin

Clinical Cancer Research · 2004 · 1,233 citations

Phenolic anti-inflammatory antioxidant reversal of AÎ²-induced cognitive deficits and neuropathology

Neurobiology of Aging · 2001 · 510 citations

Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo

Journal of Biological Chemistry · 2004 · 2,288 citations

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