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A decrease of the butyrate-producing species <i>Roseburia hominis</i> and <i>Faecalibacterium prausnitzii</i> defines dysbiosis in patients with ulcerative colitis
Gut · 2013 · Vol. 63(8) · pp. 1275–1283
Kathleen Machiels✉(KU Leuven)Marie Joossens(Vrije Universiteit Brussel)João Sabino(KU Leuven)Vicky De Preter(KU Leuven)Ingrid Arijs(KU Leuven)Venessa Eeckhaut(Ghent University)Vera Ballet(KU Leuven)Karolien Claes(KU Leuven)Filip Van Immerseel(Ghent University)Kristin Verbeke(KU Leuven)Marc Ferrante(KU Leuven)Jan Verhaegen(KU Leuven)Paul Rutgeerts(KU Leuven)Séverine Vermeire(KU Leuven)
Abstract
The composition of the fecal microbiota of UC patients differs from that of healthy individuals: we found a reduction in R hominis and F prausnitzii, both well-known butyrate-producing bacteria of the Firmicutes phylum. These results underscore the importance of dysbiosis in IBD but suggest that different bacterial species contribute to the pathogenesis of UC and CD.
Gut microbiota and healthInflammatory Bowel DiseaseClostridium difficile and Clostridium perfringens researchFaecalibacterium prausnitziiDysbiosisRoseburiaUlcerative colitisButyrateFirmicutesMicrobiologyBiologyInflammatory bowel diseaseEubacterium
MeSH terms
AdultColitis, UlcerativeFecesFemaleHumansMaleMiddle AgedPropionatesSeverity of Illness IndexCase-Control StudiesGram-Negative Anaerobic Straight, Curved, and Helical RodsLactic AcidButyric AcidBacterial LoadDenaturing Gradient Gel Electrophoresis
Citations
1,868
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55
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100%
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References
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Proceedings of the National Academy of Sciences · 2007 · 4,550 citations
Long-term impacts of antibiotic exposure on the human intestinal microbiota
Microbiology · 2010 · 1,069 citations
Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: A study with relevance to inflammatory bowel disease
World Journal of Gastroenterology · 2007 · 839 citations
Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease
Gut · 2000 · 1,308 citations
Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives
Gut · 2011 · 1,053 citations
<i>Faecalibacterium prausnitzii</i> is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Proceedings of the National Academy of Sciences · 2008 · 4,255 citations
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Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice
Infection and Immunity · 1998 · 1,472 citations
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