article Open AccessTop 10% cited
Use of immunohistochemical markers can refine prognosis in triple negative breast cancer
BMC Cancer · 2007 · Vol. 7(1) · pp. 134–134
Marc Tischkowitz✉(McGill University Health Centre)Jean‐Sébastien Brunet(BioPhage Pharma (Canada))Louis R. Bégin(Hôpital du Sacré-Cœur de Montréal)David G. Huntsman(BC Cancer Agency)Maggie C.U. Cheang(BC Cancer Agency)Lars A. Akslen(Haukeland University Hospital)Torsten O. Nielsen(BC Cancer Agency)William D. Foulkes(McGill University)
Abstract
Our findings suggests that CK5/6 and/or EGFR expressing tumor types have a persistently poorer prognosis over the longer term, an observation that may have important therapeutic implications as drugs that target the EGFR are currently being evaluated in breast cancer.
Breast Cancer Treatment StudiesHER2/EGFR in Cancer ResearchBreast Lesions and CarcinomasImmunohistochemistryBreast cancerMedicineSurgical oncologyTriple-negative breast cancerBasal (medicine)Triple negativePhenotypeOncologyInternal medicine
MeSH terms
AdultAgedBreast NeoplasmsFemaleFollow-Up StudiesHumansImmunohistochemistryMiddle AgedPrognosisReceptors, EstrogenReceptors, ProgesteroneRetrospective StudiesBiomarkers, TumorCohort StudiesSurvival Analysis
Funding
- Sanofi
- Canadian Breast Cancer Research Alliance
- Michael Smith Health Research BC
- Jewish General Hospital
Citations
367
FWCI
14.45
field-weighted impact
References
34
Percentile
99%
vs. same field & year
Citations per year
Cited by
Triple negative breast cancer: molecular profiling and prognostic impact in adjuvant anthracycline-treated patients
Breast Cancer Research and Treatment · 2007 · 319 citations
Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies
PLoS Medicine · 2010 · 1,150 citations
Triple negative breast cancer: unmet medical needs
Breast Cancer Research and Treatment · 2010 · 325 citations
Tumor-infiltrating lymphocytes are correlated with response to neoadjuvant chemotherapy in triple-negative breast cancer
Breast Cancer Research and Treatment · 2011 · 303 citations
References
Molecular portraits of human breast tumours
Nature · 2000 · 16,173 citations
Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma
Clinical Cancer Research · 2004 · 2,652 citations
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Proceedings of the National Academy of Sciences · 2001 · 10,888 citations
Expression of Cytokeratins 17 and 5 Identifies a Group of Breast Carcinomas with Poor Clinical Outcome
American Journal Of Pathology · 2002 · 563 citations
The Triple Negative Paradox: Primary Tumor Chemosensitivity of Breast Cancer Subtypes
Clinical Cancer Research · 2007 · 2,107 citations
Repeated observation of breast tumor subtypes in independent gene expression data sets
Proceedings of the National Academy of Sciences · 2003 · 5,398 citations
Race, Breast Cancer Subtypes, and Survival in the Carolina Breast Cancer Study
JAMA · 2006 · 3,808 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.