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The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults

Free Radical Biology and Medicine · 2003 · Vol. 34(4) · pp. 496–502
Levi YantQitao RanLin RaoHolly Van RemmenToru ShibataniJason G BelterLucia MottaArlan RichardsonTomas A. Prolla
Selenium in Biological SystemsSex and Gender in HealthcareGPX4Phospholipid-hydroperoxide glutathione peroxidaseLipid peroxidationOxidative stressChemistryAntioxidantCell biologySelenoproteinGlutathione peroxidaseBiochemistry

MeSH terms

Phospholipid Hydroperoxide Glutathione PeroxidaseAnimalsCell LineEmbryo, MammalianFemaleFetal DeathEmbryonic and Fetal DevelopmentFibroblastsGamma RaysGestational AgeGlutathione PeroxidaseHydrogen PeroxideMice, Inbred C57BLParaquatPregnancy

Funding

  • U.S. Department of Veterans Affairs
  • National Institutes of Health
  • University of Texas Health Science Center at San Antonio
  • National Cancer Institute
Citations
809
FWCI
13.26
field-weighted impact
References
26
Percentile
99%
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Citations per year
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References
Tissue-specific functions of individual glutathione peroxidases
Free Radical Biology and Medicine · 1999 · 1,107 citations
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The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults · Scinovex