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Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection

Annals of Internal Medicine · 2000 · Vol. 133(1) · pp. 21–30

David L. Paterson✉(University of Nebraska Medical Center)Susan Swindells(University of Nebraska Medical Center)Jeffrey Mohr(University of Nebraska Medical Center)Michelle Brester(University of Nebraska Medical Center)Emanuel N. Vergis(University of Nebraska Medical Center)Cheryl Squier(University of Nebraska Medical Center)Marilyn M. Wagener(University of Nebraska Medical Center)Nina Singh(University of Nebraska Medical Center)

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Abstract

Adherence to protease inhibitor therapy of 95% or greater optimized virologic outcome for patients with HIV infection. Diagnosis and treatment of psychiatric illness should be further investigated as a means to improve adherence to therapy.

HIV/AIDS Research and Interventions HIV/AIDS drug development and treatment HIV-related health complications and treatmentsMedicineInternal medicineProtease inhibitor (pharmacology)Veterans AffairsObservational studyViral loadProspective cohort studyAntiretroviral therapyHuman immunodeficiency virus (HIV)Immunology

MeSH terms

AdultMental DisordersFemaleFollow-Up StudiesHospitalizationHumansMaleMiddle AgedPatient ComplianceProspective StudiesProtease InhibitorsSurveys and QuestionnairesRisk FactorsStatistics as TopicHIV Infections

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A prospective study of predictors of adherence to combination antiretroviral medication