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Toward Defining the Course of Evolution: Minimum Change for a Specific Tree Topology

Systematic Biology · 1971 · Vol. 20(4) · pp. 406–416
W. M. Fitch

Abstract

Toward defining the course of evolution: minimum change for a specific tree topology. Syst. Zool., 20:406–416.—A method is presented that is asserted to provide all hypothetical ancestral character states that are consistent with describing the descent of the present-day character states in a minimum number of changes of state using a predetermined phylogenetic relationship among the taxa represented. The character states used as examples are the four messenger RNA nucleotides encoding the amino acid sequences of proteins, but the method is general.

Genetic diversity and population structureGenomics and Phylogenetic StudiesEvolution and Genetic DynamicsCharacter (mathematics)Phylogenetic treeBiologyTree (set theory)Evolutionary biologyTopology (electrical circuits)Quantitative biologyState (computer science)TaxonGenetics

Funding

  • National Science Foundation
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References
Methods for Computing Wagner Trees
Systematic Biology · 1970 · 1,231 citations
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