article Open AccessTop 1% cited
Activation of the p62‐Keap1‐NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells
Hepatology · 2015 · Vol. 63(1) · pp. 173–184
Xiaofang Sun(Third Affiliated Hospital of Guangzhou Medical University)Zhanhui Ou(Guangzhou Medical University)Ruochan Chen(UPMC Hillman Cancer Center)Xiaohua Niu(Guangzhou Medical University)De Chen(Third Affiliated Hospital of Guangzhou Medical University)Rui Kang(UPMC Hillman Cancer Center)Daolin Tang✉(UPMC Hillman Cancer Center)
Abstract
These findings demonstrate novel molecular mechanisms and signaling pathways of ferroptosis; the status of NRF2 is a key factor that determines the therapeutic response to ferroptosis-targeted therapies in HCC cells.
Ferroptosis and cancer prognosisRNA modifications and cancerGenomics, phytochemicals, and oxidative stressKEAP1Gene knockdownCancer researchTranscription factorSorafenibChemistryHeme oxygenaseFerritinHemeHepatocellular carcinoma
MeSH terms
Kelch-Like ECH-Associated Protein 1AnimalsCarcinoma, HepatocellularHumansIronLiver NeoplasmsMice, Inbred C57BLTumor Cells, CulturedSignal TransductionRNA-Binding ProteinsCell DeathIntracellular Signaling Peptides and ProteinsNF-E2-Related Factor 2Mice
Funding
- University of Pittsburgh
- National Natural Science Foundation of China
- National Institutes of Health
Citations
1,974
FWCI
24.87
field-weighted impact
References
40
Percentile
100%
vs. same field & year
Citations per year
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References
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